Recent studies highlight the potential of grapes to provide photoprotection.
Recent research published in journals Antioxidant Eating grapes has been shown to prevent UV damage to the skin. Study participants who consumed 2¼ cups of grapes daily for two weeks showed increased resistance to sunburn. The study also found a potential correlation between gut and skin, as participants with UV tolerance also had unique microbiomics and metabolomics profiles. It has been suggested that naturally occurring compounds called polyphenols may be involved in these protective effects.
This new study enhances previous work in this area. In this study of 29 human volunteers, the researchers examined the effects on UV photodamage when he ingested whole grape powder equivalent to 2¼ cups of grapes per day for 14 days. . The subject’s skin response to UV light was measured before and after her 2-week intake of grapes, and the threshold dose of UV light that induces visible redness 24 hours later, the minimal erythemal dose (MED), was determined. In addition, metabolomics analyzes of gut microbiota, blood, and urine samples were performed.
Ultimately, one-third of subjects showed UV tolerance after ingestion of grapes, and these same subjects showed significant differences in their microbiome and metabolome compared to non-responders. Notably, the same three her urinary metabolites were suppressed in the UV-tolerant group. One of her metabolites in particular (2′-deoxyribose) is a strong indicator of reduced photodamage, suggesting a unique genetic profile relevant to personalized medicine.
Furthermore, three of the UV-tolerant subjects showed a sustained response with UV protection that persisted after going back to grape abstinence for an additional 4 weeks. This study suggests that a portion of the population can resist sunburn after consuming grapes, and that there is a correlation between the gut-cutaneous axis and UV resistance.
More than 3 million Americans develop skin cancer each year, primarily as a result of sun exposure. It is estimated that one in five of her Americans will develop skin cancer by the age of 70. Most skin cancer cases are related to exposure to ultraviolet light from the sun. respectively, about 90% of non-melanoma skin cancers and his 86% of melanomas. Additionally, an estimated 90% of skin aging is caused by the sun.
“‘Make your food your medicine, and your medicine your food,'” said John Pezuto, lead author of the paper and professor and dean of Western New England University in Springfield, Massachusetts. dates back to the time of Hippocrates.2500 years later, we are still learning the reality of this statement, as this human study done with edible grapes shows.”
See: “Short-Term Grape Consumption Reduces UV-Induced Skin Erythema,” John M. Pezzuto, Asim Dave, Eun-Jung Park, Diren Beyoğlu, Jeffrey R. Idle, 30 November 2022, Available here. Antioxidant.
This study was funded by the California Table Grape Board. Funders were not involved in the production of the paper. In collecting, analyzing and interpreting data. Writing a report. or in a decision to submit a paper for publication.