January 31, 2023
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Disclosure: Zhu does not report relevant financial disclosures. See research for relevant financial disclosures of all other authors.
Vitamin B status was inversely associated with the incidence of metabolic syndrome in black and white young adults in the United States, according to an analysis of the CARDIA study published in . JAMA network open.
“To the best of our knowledge, these vitamin B intakes and Onset of metabolic syndrome Among the general adult population of the United States, Jie Zhu, MD, PhD, Written by assistant professor of nutrition and food programs at the University of Texas School of Family and Consumer Sciences, and colleagues.
In this prospective study, 4,414 black and white adolescents aged 18 to 30 years (mean age 24.9 years, 52.8% women, 50.4% black) from four major US metropolitan areas in 1985 and 1986 was included. Serum concentrations of folate, vitamin B6, and vitamin B12 were measured at years 0, 7, and 20, and at years 0, 7, and 15.
Overall, 1,240 cases of metabolic syndrome occurred during the 30-year follow-up period. After adjusting for possible confounders, the incidence of metabolic syndrome was significantly lower among those in the highest and lowest quintiles of vitamin B intake. P. < .001), vitamin B6 (HR = 0.61; 95% CI, 0.46–0.81; P. = .002) and vitamin B12 (HR = 0.74; 95% CI, 0.58–0.95; P. = .008).
Similarly, the incidence of metabolic syndrome was significantly lower in those with high versus low serum concentrations of folic acid (HR = 0.23; 95% CI 0.17-0.33; 95% CI 0.17-0.33; P. < .001), vitamin B6 (HR = 0.48; 95% CI, 0.34–0.67; P. < .001) and vitamin B12 (HR = 0.7; 95% CI, 0.51–0.96; P. = .01).
“The robustness of our findings is supported by consistent results for these B vitamin intakes and serum concentrations,” the researchers wrote. “Our findings on serum vitamin B concentrations are consistent with a case-control study that reported low plasma vitamin B6 concentrations in Nigerian patients with metabolic syndrome and a cross-sectional study that found an inverse correlation between blood. Folic Acid, Vitamin B6, Vitamin B12 and Metabolic Syndrome Prevalence in various populations. ”
